Farelerde Pentilenetetrazol ile İndüklenen Epilepsi Modelinde Agmatinin Etkilerinin ve Nitrik Oksitin Katkısının Araştırılması

Objective: Agmatine is an endogenous cationic amin and have been reported several neurotherapeutic effects through α2-adrenoceptors, imidazoline binding sites, inhibition of NMDA receptors nitric oxide (NO) synthase. NO was to act as a neuromodulator neurotransmitter in central nervous system has proconvulsant/anticonvulsant activities convulsion models. We aimed compare the anticonvulsant agmatine, sodium valproate, gabapentin phenytoin, investigate role drugs. Material Methods: Epilepsy seizures were induced swiss-albino mice by single dose injection penthylenetetrazole (PTZ) (60 mg/kg). Myoclonic-jerk (MJ) generalized tonic-clonic (GTCS) recorded. (10 mg/kg), valproate (150 (20 mg/kg) phenytoin alone or combinations with N(G)-Nitro-L-arginine-methyl-ester (L-NAME, 5 precursor NO, L-arginine (L-Arg, 60 non-specific synthase inhibitor, injected intraperitoneally. Results: While agmatine significantly prevented GTCS%, did not prevent. L-Arg reduced activity on MJ%. Both L-NAME affect MJ% GTCS%. change increased Conclusion: This study suggested that may but those phenytoin.